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Introducing DermiSphereTM

DermiSphereTM is a single-use three-dimensional acellular dermal matrix comprised of crosslinked bovine collagen microspheres embedded in bovine collagen hydrogel. In animal models, DermiSphereTM Micropatterned Wound Dressing optimized a unique scaffold microarchitecture with native hydrogel properties and mechanical cues ideal for promoting neovascularization, tissue regeneration, and wound management. 1,2
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DermiSphere™ Indications

DermiSphereTM is indicated for use in the management of wounds, including:

  • Partial and Full-Thickness Wounds
  • Pressure Ulcers
  • Venous Ulcers
  • Diabetic Ulcers
  • Chronic Vascular Ulcers
  • Surgical Wounds - donor sites/grafts, post-Mohs surgery, post laser surgery, podiatric, wound dehiscence
  • Trauma Wounds - abrasions, lacerations, second-degree burns, and skin tears
  • Draining Wounds

DermiSphereTM: A Collagen Microsphere Dermal Regeneration Template

In a porcine model of full-thickness skin loss, DermiSphereTM successfully supported simultaneous split thickness skin grafting by rapidly inducing functional vascularized neodermal tissue deposition. 2

In a novel 2-stage rat model of full thickness skin loss that closely mimics clinical practice, the composite hydrogel induced rapid cell infiltration and neovascularization, creating a healthy neodermis after only 1 week onto which a skin graft could be placed. 1
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  1. Weisel A, Cohen R, Spector JA, Sapir-Lekhovitser Y. Accelerated vascularization of a novel collagen hydrogel dermal template. J Tissue Eng Regen Med. 2022;16(12):1173-1183. doi:10.1002/term.3356
  2. Luong D, Weisel A, Cohen R, Spector J, Sapir-Lekhovitser Y. Successful reconstruction of full-thickness skin defects in a swine model using simultaneous split-thickness skin grafting and composite collagen microstructured dermal scaffolds [published online ahead of print, 2023 Jun 14]. Wound Repair Regen. 2023;10.1111/wrr.13102. doi:10.1111/wrr.13102

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