The First and Only hydrogel Dermal Regeneration Template

Hydrogel Science, Reimagined—Dual-Density Design Accelerating the Future of Dermal Regeneration

Fesarius Therapeutics

Enhancing lives with innovative technology

At Fesarius Therapeutics, we are dedicated to enhancing patient quality of life through innovative technology. The company’s flagship product, DermiSphere™ hDRT, is a novel hydrogel Dermal Regenerative Template developed from groundbreaking technology discovered by renowned plastic surgeon Dr. Jason Spector, who witnessed the limitations of current treatment options firsthand.

This highly tunable solution blends scientific efficacy with clinical needs, providing an utterly innovative hydrogel, collagen-based dermal regeneration template that maintains ideal conditions in the wound bed. In a field that has largely remained unchanged for decades, DermiSphere™ (hDRT) is poised to offer a new solution for full-thickness skin loss.

Collagen Hydrogel, Redefined

Dual Density collagen hydrogel template supporting stable vascularized tissue regeneration.

DermiSphere™ hDRT is a unique biomaterial; its name, hDRT, reflects this. It is the only genuine hydrogel dermal regeneration template available on the market.

DermiSphere hDRT maintains a novel microarchitecture elegantly crafted to have differential density interfaces. This is achieved by merging a collagen-based hydrogel with denser collagen microspheres. The patient’s collagen quickly replaces the less-dense hydrogel, while the denser microspheres are replaced more slowly, mimicking the body's natural healing response. This allows stable vascularized new tissue to form in a timely manner, which is essential when treating full-thickness skin loss.

Pre-Clinical Data Demonstrates Reliable Integration and Vascularization

Consistent  cellular invasion and early neodermis formation

In a pre-clinical study, DermiSphereTMhDRT facilitated fast and effective cellular invasion and vascularization of the template, leading to early, reliable deposition of functional neodermal tissue. By Day 3, DermiSphereTMhDRT demonstrated 100% wound bed incorporation and fully vascularized the template by Day 7 (Figure 1).1 Assessment of the newly formed dermal tissue revealed robust dermal thickness in DermiSphereTMhDRT treated wounds of 1.5mm on day 7.1
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The DermiSphereTM Difference

In a pre-clinical study, DermiSphereTM hDRT facilitated fast and effective cellular invasion and vascularization of the template, leading to early, reliable deposition of functional neodermal tissue. By Day 3, DermiSphereTM hDRT demonstrated 100% wound bed incorporation and fully vascularized the template by Day 7 (Figure 1).1 Assessment of the newly formed dermal tissue revealed robust dermal thickness in DermiSphereTM hDRT treated wounds of 1.5mm on day 7.1

MAXIMIZED CONFORMABILITY

A pliable biomaterial that conforms to native tissue

The collagen hydrogel formula is designed to maximize
conformability, ensuring that DermiSphereTM hDRT
maintains intimate contact with the wound bed,
even in irregular wound topographies, ensuring
support of the wound healing process.

IMPROVED EASE OF USE

A translucent template that supports multidirectional cell invasion

DermiSphereTM hDRT is omnidirectional and can
be applied or adjusted in any direction without
compromising its fit or function. Additionally, it can
be trimmed in the wound bed, improving its ease of
use and simplifying the need to manage it clinically.

Choose the DermiSphereTM Difference

Please call customer service
for more information:
1-833-900-HDRT
‍
customerservice@fesariustherapeutics.com
More DermiSphere hDRT
  1. Data on file. Fesarius Therapeutics, NY, NY. Pre-clinical results do not necessarily translate to clinical outcomes.
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